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123 , 124 This may be due to impaired function and/or amount of trans locator protein in the mitochondrial membrane, which would impair transport of ATP from the mitochondria into the cytoplasm and into the plasma

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The process in turn activates other transcription factors (TFs) such as Nuclear factor NF-kappa-B (NFKB1), Nuclear factor erythroid 2-related factor 2 (NRF2), and Transcription factor Sp1, also known as specificity protein 1 (SPI)